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Research chemical Published: limited Emerging use

VIP: dosing, reconstitution and evidence

A 28-amino-acid peptide with broad anti-inflammatory and immune-regulating effects. Best known in chronic inflammatory response syndrome protocols, where it is used to normalise inflammatory markers after other steps.

Also known as Vasoactive Intestinal Peptide, Aviptadil

Educational research reference Immune
Quick reference. Everything you need to run VIP — dosing, frequency, reconstitution math for the vial sizes people actually buy, and what it stacks with. For anything specific to your situation, ask the Guru.

VIP quick start

Route
SubQ, or nasal spray
Typical dose
50 mcg per spray, 4× daily
Frequency
Up to 4× daily
Half-life
About 1 minute in circulation — extremely short, which is why frequent nasal dosing is the norm.
Cycle
Months, under supervision, within a structured protocol.
Vial sizes sold
5mg or 10mg
These are the numbers people actually run, drawn from the published record and from what the community has settled on over time. Educational reference, not medical advice — a starting point to work from, and one you can adjust as you learn how you respond.

How to run it

How often
Up to 4× daily
Cycle length
Months, under supervision, within a structured protocol.
Half-life
About 1 minute in circulation — extremely short, which is why frequent nasal dosing is the norm.
Route
SubQ, or nasal spray
Consistency matters more than perfect timing. Pick a slot in your day you will actually keep, and let DoseIQ handle the rest.

What people actually run

Used almost entirely within CIRS and mold-illness protocols, where it is the final step after everything else. Nasal spray is the standard route.

This is accumulated community practice — years of real-world use across a large number of people, converging on numbers that work. It is not a controlled trial, and for most compounds here no such trial exists or is ever likely to. That makes this the most reliable dosing signal available, and it is a good deal better than guessing.

What to expect

Most people tolerate VIP well. Here is what is worth knowing going in, so nothing catches you by surprise.

Can drop blood pressure — VIP is a vasodilator — so stand up slowly for the first few doses. Within CIRS protocols it is deliberately the last step, because using it before addressing exposure and other markers is reported to be ineffective and wastes an expensive compound. Genuinely thin evidence outside that specific context.

Reconstitution guide

VIP ships as a lyophilised powder and gets mixed with bacteriostatic water before use. How much water you add sets the concentration, which sets how many syringe units make up each dose. One unit on a U-100 syringe is 0.01 mL — the tables below do the arithmetic for the vial sizes you are most likely to be holding.

5mg vial most common

Water addedConcentration 50mcg
2mL (common) 2.5 mg/mL0.02 mL
2 units
3mL 1.67 mg/mL0.03 mL
3 units

10mg vial

Water addedConcentration 50mcg
2mL (common) 5 mg/mL0.01 mL
1 units
3mL 3.33 mg/mL0.01 mL
1.5 units
5 mg vial + 1 mL BAC water = 5 mg/mL — a 500 mcg dose = 10 units on a U-100 syringe. 10 mg vial + 2 mL = 5 mg/mL — 500 mcg = 10 units. Also compounded into a nasal spray, where the mix is diluted in the spray bottle rather than the vial.

Standard steps

  1. Inspect the vialConfirm the label and that the powder cake is intact. Do not use a cracked or compromised vial.
  2. Let it reach room temperatureSitting out for a few minutes reduces condensation inside the vial when the seal is broken.
  3. Disinfect both stoppersWipe the compound vial and the bacteriostatic water vial with a fresh alcohol swab and let them air-dry.
  4. Draw the bacteriostatic waterUse a sterile syringe to draw the volume you have chosen from the reconstitution table.
  5. Add the water down the vial wallInject slowly so it runs down the inside wall rather than spraying directly onto the powder. This limits foaming.
  6. Dissolve gentlySwirl or roll the vial between your hands until the cake dissolves. Never shake — agitation damages peptide bonds. The solution should end up clear.
  7. Label and refrigerateWrite the reconstitution date and concentration on the vial. Store at 2–8°C. Do not freeze.
Running a different vial size or water volume? The DoseIQ calculator works it out for any combination — mcg, mg or IU, on any syringe size.
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This page is an educational research reference and is not medical advice. VIP is not approved for human use in any jurisdiction. Dose figures reflect the published record and what the community has converged on — starting points to weigh, not instructions. Consult a qualified healthcare provider before starting any protocol.