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Research chemical Published: human trials Emerging use

Tesofensine: dosing, timing and what to expect

A triple monoamine reuptake inhibitor — dopamine, noradrenaline and serotonin — originally trialled for Parkinson's, where the weight loss was noticed as a side effect. Approved in Mexico for obesity.

Also known as NS2330

Educational research reference Metabolic & Weight
Quick reference. Everything you need to run Tesofensine — dosing, frequency, reconstitution math for the vial sizes people actually buy, and what it stacks with. For anything specific to your situation, ask the Guru.

Tesofensine quick start

Route
Oral
Typical dose
0.25–0.5 mg daily
Frequency
Once daily, in the morning
Half-life
About 220 hours, which is very long — effects accumulate over weeks and clear slowly.
Cycle
Typically 12–24 weeks, then a break.
These are the numbers people actually run, drawn from the published record and from what the community has settled on over time. Educational reference, not medical advice — a starting point to work from, and one you can adjust as you learn how you respond.

How to run it

How often
Once daily, in the morning
Cycle length
Typically 12–24 weeks, then a break.
Half-life
About 220 hours, which is very long — effects accumulate over weeks and clear slowly.
Route
Oral
Consistency matters more than perfect timing. Pick a slot in your day you will actually keep, and let DoseIQ handle the rest.

What people actually run

Oral, and quite different from the injectables — this is a stimulant-type appetite suppressant rather than an incretin.

This is accumulated community practice — years of real-world use across a large number of people, converging on numbers that work. It is not a controlled trial, and for most compounds here no such trial exists or is ever likely to. That makes this the most reliable dosing signal available, and it is a good deal better than guessing.

What to expect

Most people tolerate Tesofensine well. Here is what is worth knowing going in, so nothing catches you by surprise.

This is a stimulant in effect if not in name. It raises heart rate and blood pressure, and the very long half-life means it accumulates — start at 0.25 mg and do not escalate quickly. Insomnia and dry mouth are the common complaints; take it in the morning. Serious interaction risk with MAOIs, SSRIs and other serotonergic drugs, which is a conversation for a doctor rather than a forum.

Known interactions

Interactions involving Tesofensine's drug class that DoseIQ screens for. Each one cites where it comes from — an FDA label section or the published record — because an interaction warning you can't trace is just noise.

Caution Multiple serotonergic drugs — additive load

Each additional serotonergic agent (SSRI, trazodone, buspirone) adds to total serotonergic load; interactions range from mild to, rarely, serotonin syndrome.

What to do: This combination is usually deliberate and fine — but every prescriber involved should know the full list.

Source: FDA labels, SSRI class §7

Caution SSRIs + melanocortins (PT-141, MT-2) — central overlap

Both act centrally; the community reports stronger nausea and blunted or altered response on the combination.

What to do: Start at the low end of melanocortin dosing and judge your own response.

Source: Community reports; melanocortin pharmacology

Caution Stimulant + bupropion — additive blood pressure and seizure threshold

Both raise blood pressure and heart rate, and bupropion lowers the seizure threshold — additive in both directions.

What to do: A common, usually-fine prescription combo — but it should be a deliberate one both prescribers know about. BP is worth logging.

Source: FDA label, bupropion §7

DoseIQ screens your whole protocol against these rules automatically — every compound, prescription and supplement you track, cross-checked as you add them. Serious flags are always free.

Preparing it

Tesofensine does not need reconstituting — it comes ready to use. Oral capsules or drops. Nothing to reconstitute.
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This page is an educational research reference and is not medical advice. Tesofensine is not approved for human use in any jurisdiction. Dose figures reflect the published record and what the community has converged on — starting points to weigh, not instructions. Consult a qualified healthcare provider before starting any protocol.