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Compounded Published: RCT evidence Established use

Sermorelin: dosing, reconstitution and evidence

The first 29 amino acids of GHRH — the shortest fully active fragment. Previously FDA-approved for pediatric growth hormone deficiency; now widely available through compounding pharmacies for adult anti-aging use.

Also known as GHRH(1-29), Geref

Educational research reference Growth Hormone
Quick reference. Everything you need to run Sermorelin — dosing, frequency, reconstitution math for the vial sizes people actually buy, and what it stacks with. For anything specific to your situation, ask the Guru.

Sermorelin quick start

Route
SubQ
Typical dose
200–500 mcg
Frequency
Nightly at bedtime
Half-life
Roughly 10–20 minutes.
Cycle
3–6 months, physician-monitored.
Vial sizes sold
5mg or 10mg
These are the numbers people actually run, drawn from the published record and from what the community has settled on over time. Educational reference, not medical advice — a starting point to work from, and one you can adjust as you learn how you respond.

How to run it

How often
Nightly at bedtime
Cycle length
3–6 months, physician-monitored.
Half-life
Roughly 10–20 minutes.
Route
SubQ
Consistency matters more than perfect timing. Pick a slot in your day you will actually keep, and let DoseIQ handle the rest.

What people actually run

Common entry point, partly because it is prescribable through compounding pharmacies.

This is accumulated community practice — years of real-world use across a large number of people, converging on numbers that work. It is not a controlled trial, and for most compounds here no such trial exists or is ever likely to. That makes this the most reliable dosing signal available, and it is a good deal better than guessing.

What to expect

Most people tolerate Sermorelin well. Here is what is worth knowing going in, so nothing catches you by surprise.

One of the few here with genuine FDA history and legitimate prescription access. Injection-site redness is common. Requires an intact pituitary to work.

Known interactions

Interactions involving Sermorelin's drug class that DoseIQ screens for. Each one cites where it comes from — an FDA label section or the published record — because an interaction warning you can't trace is just noise.

Caution GH peptides push blood sugar against your diabetes medication

Growth hormone raises glucose and insulin resistance — it works directly against glucose-lowering medication.

What to do: Fasting glucose and HbA1c are worth tracking; medication doses sometimes need adjusting. Your prescriber should know GH peptides are in the picture.

Source: GH pharmacology; tesamorelin label §7

DoseIQ screens your whole protocol against these rules automatically — every compound, prescription and supplement you track, cross-checked as you add them. Serious flags are always free.

Reconstitution guide

Sermorelin ships as a lyophilised powder and gets mixed with bacteriostatic water before use. How much water you add sets the concentration, which sets how many syringe units make up each dose. One unit on a U-100 syringe is 0.01 mL — the tables below do the arithmetic for the vial sizes you are most likely to be holding.

5mg vial most common

Water addedConcentration 200mcg500mcg
2mL (common) 2.5 mg/mL0.08 mL
8 units		0.20 mL
20 units
3mL 1.67 mg/mL0.12 mL
12 units		0.30 mL
30 units

10mg vial

Water addedConcentration 200mcg500mcg
2mL (common) 5 mg/mL0.04 mL
4 units		0.10 mL
10 units
3mL 3.33 mg/mL0.06 mL
6 units		0.15 mL
15 units
5 mg vial + 2.5 mL BAC water = 2 mg/mL — a 300 mcg dose = 15 units on a U-100 syringe. 10 mg vial + 3 mL = 3,333 mcg/mL — 300 mcg = 9 units.

Standard steps

  1. Inspect the vialConfirm the label and that the powder cake is intact. Do not use a cracked or compromised vial.
  2. Let it reach room temperatureSitting out for a few minutes reduces condensation inside the vial when the seal is broken.
  3. Disinfect both stoppersWipe the compound vial and the bacteriostatic water vial with a fresh alcohol swab and let them air-dry.
  4. Draw the bacteriostatic waterUse a sterile syringe to draw the volume you have chosen from the reconstitution table.
  5. Add the water down the vial wallInject slowly so it runs down the inside wall rather than spraying directly onto the powder. This limits foaming.
  6. Dissolve gentlySwirl or roll the vial between your hands until the cake dissolves. Never shake — agitation damages peptide bonds. The solution should end up clear.
  7. Label and refrigerateWrite the reconstitution date and concentration on the vial. Store at 2–8°C. Do not freeze.
Running a different vial size or water volume? The DoseIQ calculator works it out for any combination — mcg, mg or IU, on any syringe size.
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This page is an educational research reference and is not medical advice. Dose figures reflect the published record and what the community has converged on — starting points to weigh, not instructions. Consult a qualified healthcare provider before starting any protocol.