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Prescription drug Published: RCT evidence Established use

Progesterone: dosing, timing and what to expect

A primary female sex hormone used in HRT, typically alongside estradiol to protect the endometrium. Also used for sleep and mood.

Also known as Prometrium, Micronized progesterone

Educational research reference TRT / HRT & Ancillary
Quick reference. Everything you need to run Progesterone — dosing, frequency, reconstitution math for the vial sizes people actually buy, and what it stacks with. For anything specific to your situation, ask the Guru.

Progesterone quick start

Route
Oral, topical or vaginal
Typical dose
100–200 mg
Frequency
Nightly
Half-life
Roughly 5–20 hours depending on formulation.
Cycle
Continuous or cyclic per HRT protocol.
These are the numbers people actually run, drawn from the published record and from what the community has settled on over time. Educational reference, not medical advice — a starting point to work from, and one you can adjust as you learn how you respond.

How to run it

How often
Nightly
Cycle length
Continuous or cyclic per HRT protocol.
Half-life
Roughly 5–20 hours depending on formulation.
Route
Oral, topical or vaginal
Consistency matters more than perfect timing. Pick a slot in your day you will actually keep, and let DoseIQ handle the rest.

For women

Micronized progesterone in HRT: 100 mg nightly continuous (postmenopause) or 200 mg nightly on cycle days 15–26 (perimenopause). Bedtime dosing on purpose — the sedation is a feature.

What to expect

Most people tolerate Progesterone well. Here is what is worth knowing going in, so nothing catches you by surprise.

Prescription. Causes marked sedation — take at night. Micronized (bioidentical) progesterone has a better cardiovascular and breast profile than synthetic progestins. Required with estrogen in anyone with an intact uterus.

Known interactions

Interactions involving Progesterone's drug class that DoseIQ screens for. Each one cites where it comes from — an FDA label section or the published record — because an interaction warning you can't trace is just noise.

Worth knowing Multiple sedating agents — additive drowsiness

Trazodone, gabapentin, micronized progesterone — each mild alone, cumulative together.

What to do: Time them all at night, and judge morning grogginess honestly.

Source: Class pharmacology

DoseIQ screens your whole protocol against these rules automatically — every compound, prescription and supplement you track, cross-checked as you add them. Serious flags are always free.

Preparing it

Progesterone does not need reconstituting — it comes ready to use. Not applicable — capsule, cream or suppository.
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This page is an educational research reference and is not medical advice. Dose figures reflect the published record and what the community has converged on — starting points to weigh, not instructions. Consult a qualified healthcare provider before starting any protocol.