Compounded Published: limited Extensive real-world use

Progesterone cream (compounded): dosing, timing and what to expect

Compounded progesterone applied to the skin, supplied anywhere from 50 to 250 mg per mL or per gram. Note that compounders list both denominators within a single product line, so the unit on the label matters.

Also known as Compounded progesterone, Progesterone topical

Educational research reference TRT / HRT & Ancillary

Quick reference. Everything you need to run Progesterone cream (compounded) — dosing, frequency, reconstitution math for the vial sizes people actually buy, and what it stacks with. For anything specific to your situation, ask the Guru.

Progesterone cream (compounded) quick start

Route: Topical
Typical dose: 5–50 mg
Frequency: Once or twice daily
Half-life: Variable and poorly characterised for the transdermal route.
Cycle: Frequently cycle-day anchored — days 14–25 is a common pattern.

These are the numbers people actually run, drawn from the published record and from what the community has settled on over time. Educational reference, not medical advice — a starting point to work from, and one you can adjust as you learn how you respond.

How to run it

How often: Once or twice daily
Cycle length: Frequently cycle-day anchored — days 14–25 is a common pattern.
Half-life: Variable and poorly characterised for the transdermal route.
Route: Topical

Consistency matters more than perfect timing. Pick a slot in your day you will actually keep, and let DoseIQ handle the rest.

For women

This is the one place where the route changes the answer to a safety question rather than just the dose. The British Menopause Society position, updated May 2026, is that micronised progesterone within an HRT regimen should not be given transdermally because it is unlikely to provide sufficient endometrial protection, and that compounded preparations are not recommended for that purpose. If you are taking a systemic estrogen and have a uterus, this is worth raising with your prescriber rather than assuming the cream is doing the same job as an oral capsule.

What to expect

Most people tolerate Progesterone cream (compounded) well. Here is what is worth knowing going in, so nothing catches you by surprise.

A systematic review cited by ACOG found the available evidence did not support progesterone cream for vasomotor symptoms. Do not treat a compounded cream as interchangeable with oral micronised progesterone for endometrial protection.

Preparing it

Progesterone cream (compounded) does not need reconstituting — it comes ready to use. Nothing to reconstitute. One click of a 100 mg/mL cream on a standard TC-35 dispenser is about 25 mg.

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This page is an educational research reference and is not medical advice. Dose figures reflect the published record and what the community has converged on — starting points to weigh, not instructions. Consult a qualified healthcare provider before starting any protocol.