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Research chemical Published: animal data only Established use

LL-37: dosing, reconstitution and evidence

The only human cathelicidin antimicrobial peptide. Broad antimicrobial and immunomodulatory activity; investigated for chronic wounds and biofilm-associated infection.

Also known as Cathelicidin, hCAP-18

Educational research reference Immune
Quick reference. Everything you need to run LL-37 — dosing, frequency, reconstitution math for the vial sizes people actually buy, and what it stacks with. For anything specific to your situation, ask the Guru.

LL-37 quick start

Route
SubQ
Typical dose
100–500 mcg
Frequency
Daily or every other day
Half-life
Short — minutes to a few hours; degraded rapidly by proteases.
Cycle
Short courses, typically 2–4 weeks.
Vial sizes sold
5mg or 10mg
These are the numbers people actually run, drawn from the published record and from what the community has settled on over time. Educational reference, not medical advice — a starting point to work from, and one you can adjust as you learn how you respond.

How to run it

How often
Daily or every other day
Cycle length
Short courses, typically 2–4 weeks.
Half-life
Short — minutes to a few hours; degraded rapidly by proteases.
Route
SubQ
Consistency matters more than perfect timing. Pick a slot in your day you will actually keep, and let DoseIQ handle the rest.

What to expect

Most people tolerate LL-37 well. Here is what is worth knowing going in, so nothing catches you by surprise.

Can be pro-inflammatory at higher concentrations and has been implicated in rosacea and psoriasis pathology. Injection site reactions are common. Not for human use.

Reconstitution guide

LL-37 ships as a lyophilised powder and gets mixed with bacteriostatic water before use. How much water you add sets the concentration, which sets how many syringe units make up each dose. One unit on a U-100 syringe is 0.01 mL — the tables below do the arithmetic for the vial sizes you are most likely to be holding.

5mg vial most common

Water addedConcentration 100mcg500mcg
2mL (common) 2.5 mg/mL0.04 mL
4 units		0.20 mL
20 units
3mL 1.67 mg/mL0.06 mL
6 units		0.30 mL
30 units

10mg vial

Water addedConcentration 100mcg500mcg
2mL (common) 5 mg/mL0.02 mL
2 units		0.10 mL
10 units
3mL 3.33 mg/mL0.03 mL
3 units		0.15 mL
15 units
5 mg vial + 2 mL BAC water = 2,500 mcg/mL — a 250 mcg dose = 10 units on a U-100 syringe. 10 mg vial + 2 mL = 5 mg/mL — 250 mcg = 5 units.

Standard steps

  1. Inspect the vialConfirm the label and that the powder cake is intact. Do not use a cracked or compromised vial.
  2. Let it reach room temperatureSitting out for a few minutes reduces condensation inside the vial when the seal is broken.
  3. Disinfect both stoppersWipe the compound vial and the bacteriostatic water vial with a fresh alcohol swab and let them air-dry.
  4. Draw the bacteriostatic waterUse a sterile syringe to draw the volume you have chosen from the reconstitution table.
  5. Add the water down the vial wallInject slowly so it runs down the inside wall rather than spraying directly onto the powder. This limits foaming.
  6. Dissolve gentlySwirl or roll the vial between your hands until the cake dissolves. Never shake — agitation damages peptide bonds. The solution should end up clear.
  7. Label and refrigerateWrite the reconstitution date and concentration on the vial. Store at 2–8°C. Do not freeze.
Running a different vial size or water volume? The DoseIQ calculator works it out for any combination — mcg, mg or IU, on any syringe size.
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This page is an educational research reference and is not medical advice. LL-37 is not approved for human use in any jurisdiction. Dose figures reflect the published record and what the community has converged on — starting points to weigh, not instructions. Consult a qualified healthcare provider before starting any protocol.