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Research chemical Published: human trials Extensive real-world use

Ipamorelin: dosing, reconstitution and evidence

The most selective ghrelin receptor agonist / GH secretagogue. Its appeal is what it does not do: minimal effect on cortisol, prolactin or appetite, unlike the older GHRPs.

Also known as NNC 26-0161

Educational research reference Growth Hormone
Quick reference. Everything you need to run Ipamorelin — dosing, frequency, reconstitution math for the vial sizes people actually buy, and what it stacks with. For anything specific to your situation, ask the Guru.

Ipamorelin quick start

Route
SubQ
Typical dose
200–300 mcg
Frequency
1–3× daily
Half-life
About 2 hours.
Cycle
12 weeks on, 4 off.
Vial sizes sold
10mg or 5mg
These are the numbers people actually run, drawn from the published record and from what the community has settled on over time. Educational reference, not medical advice — a starting point to work from, and one you can adjust as you learn how you respond.

How to run it

How often
1–3× daily
Cycle length
12 weeks on, 4 off.
Half-life
About 2 hours.
Route
SubQ
Consistency matters more than perfect timing. Pick a slot in your day you will actually keep, and let DoseIQ handle the rest.

For women

Women commonly run 60–80% of cited doses, and some time GH peptides away from the luteal phase to limit water retention.

What people actually run

The default GH secretagogue for most people. Almost always run with a GHRH like CJC-1295.

This is accumulated community practice — years of real-world use across a large number of people, converging on numbers that work. It is not a controlled trial, and for most compounds here no such trial exists or is ever likely to. That makes this the most reliable dosing signal available, and it is a good deal better than guessing.

What to expect

Most people tolerate Ipamorelin well. Here is what is worth knowing going in, so nothing catches you by surprise.

The gentlest of the GHRPs. It releases less GH than hexarelin or GHRP-6, but it also leaves cortisol and prolactin alone, which is exactly why it is the usual first choice and the one most people stay on. Some light-headedness or flushing in the first few doses is normal and settles quickly. If you have an active malignancy, hold off and speak to your doctor first.

Known interactions

Interactions involving Ipamorelin's drug class that DoseIQ screens for. Each one cites where it comes from — an FDA label section or the published record — because an interaction warning you can't trace is just noise.

Caution GH peptides push blood sugar against your diabetes medication

Growth hormone raises glucose and insulin resistance — it works directly against glucose-lowering medication.

What to do: Fasting glucose and HbA1c are worth tracking; medication doses sometimes need adjusting. Your prescriber should know GH peptides are in the picture.

Source: GH pharmacology; tesamorelin label §7

DoseIQ screens your whole protocol against these rules automatically — every compound, prescription and supplement you track, cross-checked as you add them. Serious flags are always free.

Reconstitution guide

Ipamorelin ships as a lyophilised powder and gets mixed with bacteriostatic water before use. How much water you add sets the concentration, which sets how many syringe units make up each dose. One unit on a U-100 syringe is 0.01 mL — the tables below do the arithmetic for the vial sizes you are most likely to be holding.

10mg vial most common

Water addedConcentration 200mcg300mcg
2mL (common) 5 mg/mL0.04 mL
4 units		0.06 mL
6 units
3mL 3.33 mg/mL0.06 mL
6 units		0.09 mL
9 units

5mg vial

Water addedConcentration 200mcg300mcg
2mL (common) 2.5 mg/mL0.08 mL
8 units		0.12 mL
12 units
3mL 1.67 mg/mL0.12 mL
12 units		0.18 mL
18 units
10 mg vial + 2 mL BAC water = 5 mg/mL — a 250 mcg dose = 5 units on a U-100 syringe. 5 mg vial + 2 mL = 2,500 mcg/mL — 250 mcg = 10 units.

Standard steps

  1. Inspect the vialConfirm the label and that the powder cake is intact. Do not use a cracked or compromised vial.
  2. Let it reach room temperatureSitting out for a few minutes reduces condensation inside the vial when the seal is broken.
  3. Disinfect both stoppersWipe the compound vial and the bacteriostatic water vial with a fresh alcohol swab and let them air-dry.
  4. Draw the bacteriostatic waterUse a sterile syringe to draw the volume you have chosen from the reconstitution table.
  5. Add the water down the vial wallInject slowly so it runs down the inside wall rather than spraying directly onto the powder. This limits foaming.
  6. Dissolve gentlySwirl or roll the vial between your hands until the cake dissolves. Never shake — agitation damages peptide bonds. The solution should end up clear.
  7. Label and refrigerateWrite the reconstitution date and concentration on the vial. Store at 2–8°C. Do not freeze.
Running a different vial size or water volume? The DoseIQ calculator works it out for any combination — mcg, mg or IU, on any syringe size.
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This page is an educational research reference and is not medical advice. Ipamorelin is not approved for human use in any jurisdiction. Dose figures reflect the published record and what the community has converged on — starting points to weigh, not instructions. Consult a qualified healthcare provider before starting any protocol.