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Research chemical Published: animal data only Established use

IGF-1 LR3: dosing, reconstitution and evidence

A modified IGF-1 analog with an arginine substitution and a 13-amino-acid extension that dramatically reduces binding-protein affinity — greatly increasing potency and duration versus native IGF-1.

Also known as Long R3 IGF-1

Educational research reference Growth Hormone
Quick reference. Everything you need to run IGF-1 LR3 — dosing, frequency, reconstitution math for the vial sizes people actually buy, and what it stacks with. For anything specific to your situation, ask the Guru.

IGF-1 LR3 quick start

Route
SubQ
Typical dose
20–50 mcg
Frequency
Daily
Half-life
Roughly 20–30 hours, versus about 10–20 minutes for native IGF-1.
Cycle
4 weeks maximum is the commonly cited limit.
Vial sizes sold
1mg or 5mg
These are the numbers people actually run, drawn from the published record and from what the community has settled on over time. Educational reference, not medical advice — a starting point to work from, and one you can adjust as you learn how you respond.

How to run it

How often
Daily
Cycle length
4 weeks maximum is the commonly cited limit.
Half-life
Roughly 20–30 hours, versus about 10–20 minutes for native IGF-1.
Route
SubQ
Consistency matters more than perfect timing. Pick a slot in your day you will actually keep, and let DoseIQ handle the rest.

What people actually run

Established but respected — the community treats hypoglycemia risk seriously and keeps cycles short.

This is accumulated community practice — years of real-world use across a large number of people, converging on numbers that work. It is not a controlled trial, and for most compounds here no such trial exists or is ever likely to. That makes this the most reliable dosing signal available, and it is a good deal better than guessing.

What to expect

Most people tolerate IGF-1 LR3 well. Here is what is worth knowing going in, so nothing catches you by surprise.

This one needs more respect than most. It can lower blood sugar noticeably, so keep fast carbs within reach and eat around your dose rather than fasted — that alone handles the issue for most people. It is strongly growth-promoting, so anyone with a history of malignancy should leave it alone. Start at the bottom of the range and give yourself a week before adjusting. Banned by WADA, so it is out if you compete tested.

Known interactions

Interactions involving IGF-1 LR3's drug class that DoseIQ screens for. Each one cites where it comes from — an FDA label section or the published record — because an interaction warning you can't trace is just noise.

Serious IGF-1 + diabetes medication — severe hypoglycemia risk

IGF-1 drives glucose into muscle on top of medication doing the same — this is the combination that puts people on the floor.

What to do: This pairing needs your prescriber's explicit awareness, glucose on hand, and monitoring.

Source: Community consensus + IGF-1 pharmacology; the Guru's straight-talk list

DoseIQ screens your whole protocol against these rules automatically — every compound, prescription and supplement you track, cross-checked as you add them. Serious flags are always free.

Reconstitution guide

IGF-1 LR3 ships as a lyophilised powder and gets mixed with bacteriostatic water before use. How much water you add sets the concentration, which sets how many syringe units make up each dose. One unit on a U-100 syringe is 0.01 mL — the tables below do the arithmetic for the vial sizes you are most likely to be holding.

1mg vial most common

Water addedConcentration 20mcg50mcg
1mL (common) 1 mg/mL0.02 mL
2 units		0.05 mL
5 units
2mL 500 mcg/mL0.04 mL
4 units		0.10 mL
10 units

5mg vial

Water addedConcentration 20mcg50mcg
1mL (common) 5 mg/mL0.00 mL
0.4 units		0.01 mL
1 units
2mL 2.5 mg/mL0.01 mL
0.8 units		0.02 mL
2 units
1 mg vial + 2 mL BAC water = 500 mcg/mL — a 40 mcg dose = 8 units on a U-100 syringe. 5 mg vial + 2 mL = 2,500 mcg/mL — 40 mcg = 1.6 units.

Standard steps

  1. Inspect the vialConfirm the label and that the powder cake is intact. Do not use a cracked or compromised vial.
  2. Let it reach room temperatureSitting out for a few minutes reduces condensation inside the vial when the seal is broken.
  3. Disinfect both stoppersWipe the compound vial and the bacteriostatic water vial with a fresh alcohol swab and let them air-dry.
  4. Draw the bacteriostatic waterUse a sterile syringe to draw the volume you have chosen from the reconstitution table.
  5. Add the water down the vial wallInject slowly so it runs down the inside wall rather than spraying directly onto the powder. This limits foaming.
  6. Dissolve gentlySwirl or roll the vial between your hands until the cake dissolves. Never shake — agitation damages peptide bonds. The solution should end up clear.
  7. Label and refrigerateWrite the reconstitution date and concentration on the vial. Store at 2–8°C. Do not freeze.
Running a different vial size or water volume? The DoseIQ calculator works it out for any combination — mcg, mg or IU, on any syringe size.
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This page is an educational research reference and is not medical advice. IGF-1 LR3 is not approved for human use in any jurisdiction. Dose figures reflect the published record and what the community has converged on — starting points to weigh, not instructions. Consult a qualified healthcare provider before starting any protocol.