HMG: dosing, reconstitution and evidence
Contains both FSH and LH activity. Used in fertility protocols where HCG alone (LH activity only) is insufficient, since FSH is required for spermatogenesis.
Also known as Human Menopausal Gonadotropin, Menopur, Repronex
HMG quick start
- Route
- SubQ or IM
- Typical dose
- 75–150 IU
- Frequency
- 2–3× weekly
- Half-life
- FSH component roughly 30–40 hours.
- Cycle
- Per fertility protocol, usually 3–6 months.
- Vial sizes sold
- 75 IU or 150 IU
How to run it
- How often
- 2–3× weekly
- Cycle length
- Per fertility protocol, usually 3–6 months.
- Half-life
- FSH component roughly 30–40 hours.
- Route
- SubQ or IM
What to expect
Most people tolerate HMG well. Here is what is worth knowing going in, so nothing catches you by surprise.
Reconstitution guide
HMG ships as a lyophilised powder and gets mixed with bacteriostatic water before use. How much water you add sets the concentration, which sets how many syringe units make up each dose. One unit on a U-100 syringe is 0.01 mL — the tables below do the arithmetic for the vial sizes you are most likely to be holding.
75 IU vial most common
| Water added | Concentration | 75 IU | 150 IU |
|---|---|---|---|
| 1mL (common) | 75 IU/mL | 1.00 mL 100 units | 2.00 mL 200 units * |
| 2mL | 37.5 IU/mL | 2.00 mL 200 units * | 4.00 mL 400 units * |
150 IU vial
| Water added | Concentration | 75 IU | 150 IU |
|---|---|---|---|
| 1mL (common) | 150 IU/mL | 0.50 mL 50 units | 1.00 mL 100 units |
| 2mL | 75 IU/mL | 1.00 mL 100 units | 2.00 mL 200 units * |
* More than 100 units — that is more than a single U-100 insulin syringe holds. Either use a larger syringe, split it across two draws, or mix with less water to concentrate it. Adding less water is usually the easier fix.
Standard steps
- Inspect the vialConfirm the label and that the powder cake is intact. Do not use a cracked or compromised vial.
- Let it reach room temperatureSitting out for a few minutes reduces condensation inside the vial when the seal is broken.
- Disinfect both stoppersWipe the compound vial and the bacteriostatic water vial with a fresh alcohol swab and let them air-dry.
- Draw the bacteriostatic waterUse a sterile syringe to draw the volume you have chosen from the reconstitution table.
- Add the water down the vial wallInject slowly so it runs down the inside wall rather than spraying directly onto the powder. This limits foaming.
- Dissolve gentlySwirl or roll the vial between your hands until the cake dissolves. Never shake — agitation damages peptide bonds. The solution should end up clear.
- Label and refrigerateWrite the reconstitution date and concentration on the vial. Store at 2–8°C. Do not freeze.
This page is an educational research reference and is not medical advice. Dose figures reflect the published record and what the community has converged on — starting points to weigh, not instructions. Consult a qualified healthcare provider before starting any protocol.