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Over the counter Published: limited Established use

Glutathione: dosing, reconstitution and evidence

The body's primary intracellular antioxidant. Supplemented for oxidative stress, liver support and — the reason most people actually buy it — skin brightening.

Also known as GSH, reduced glutathione

Educational research reference Longevity & Cellular
Quick reference. Everything you need to run Glutathione — dosing, frequency, reconstitution math for the vial sizes people actually buy, and what it stacks with. For anything specific to your situation, ask the Guru.

Glutathione quick start

Route
IM, IV, or SubQ
Typical dose
200–600 mg
Frequency
2–3× weekly
Half-life
Very short in circulation — minutes to a couple of hours.
Cycle
Ongoing, or in blocks of 4–8 weeks.
Vial sizes sold
600mg or 1500mg
These are the numbers people actually run, drawn from the published record and from what the community has settled on over time. Educational reference, not medical advice — a starting point to work from, and one you can adjust as you learn how you respond.

How to run it

How often
2–3× weekly
Cycle length
Ongoing, or in blocks of 4–8 weeks.
Half-life
Very short in circulation — minutes to a couple of hours.
Route
IM, IV, or SubQ
Consistency matters more than perfect timing. Pick a slot in your day you will actually keep, and let DoseIQ handle the rest.

For women

Skin brightening is the main draw for women, and the dosing is the same as men's — effect builds over weeks of consistent use, not per-dose. Fine alongside a cycle and doesn't interact with contraception; no pregnancy safety data, so most pause it while trying to conceive.

What people actually run

Sold widely alongside peptides, usually IV or IM at clinics and SubQ at home. Popular for skin brightening as much as for antioxidant claims.

This is accumulated community practice — years of real-world use across a large number of people, converging on numbers that work. It is not a controlled trial, and for most compounds here no such trial exists or is ever likely to. That makes this the most reliable dosing signal available, and it is a good deal better than guessing.

What to expect

Most people tolerate Glutathione well. Here is what is worth knowing going in, so nothing catches you by surprise.

Well tolerated. Oral glutathione is largely broken down before absorption, which is why injection is the common route — if someone is selling oral glutathione for systemic effect, that is worth knowing. Very light-sensitive and unstable once mixed, so keep it dark and cold and use it promptly. Rare reports of asthma exacerbation with inhaled forms.

Reconstitution guide

Glutathione ships as a lyophilised powder and gets mixed with bacteriostatic water before use. How much water you add sets the concentration, which sets how many syringe units make up each dose. One unit on a U-100 syringe is 0.01 mL — the tables below do the arithmetic for the vial sizes you are most likely to be holding.

600mg vial most common

Water addedConcentration 200mg600mg
3mL 200 mg/mL1.00 mL
100 units		3.00 mL
300 units *
5mL (common) 120 mg/mL1.67 mL
166.7 units *		5.00 mL
500 units *
10mL 60 mg/mL3.33 mL
333.3 units *		10.00 mL
1000 units *

1500mg vial

Water addedConcentration 200mg600mg
3mL 500 mg/mL0.40 mL
40 units		1.20 mL
120 units *
5mL (common) 300 mg/mL0.67 mL
66.7 units		2.00 mL
200 units *
10mL 150 mg/mL1.33 mL
133.3 units *		4.00 mL
400 units *

* More than 100 units — that is more than a single U-100 insulin syringe holds. Either use a larger syringe, split it across two draws, or mix with less water to concentrate it. Adding less water is usually the easier fix.

Often supplied as a lyophilised powder. 600 mg vial + 3 mL BAC water = 200 mg/mL — a 200 mg dose = 100 units on a U-100 syringe. 1500 mg vial + 10 mL = 150 mg/mL — 200 mg = 1.33 mL (use a 3 mL syringe, not an insulin syringe).

Standard steps

  1. Inspect the vialConfirm the label and that the powder cake is intact. Do not use a cracked or compromised vial.
  2. Let it reach room temperatureSitting out for a few minutes reduces condensation inside the vial when the seal is broken.
  3. Disinfect both stoppersWipe the compound vial and the bacteriostatic water vial with a fresh alcohol swab and let them air-dry.
  4. Draw the bacteriostatic waterUse a sterile syringe to draw the volume you have chosen from the reconstitution table.
  5. Add the water down the vial wallInject slowly so it runs down the inside wall rather than spraying directly onto the powder. This limits foaming.
  6. Dissolve gentlySwirl or roll the vial between your hands until the cake dissolves. Never shake — agitation damages peptide bonds. The solution should end up clear.
  7. Label and refrigerateWrite the reconstitution date and concentration on the vial. Store at 2–8°C. Do not freeze.
Running a different vial size or water volume? The DoseIQ calculator works it out for any combination — mcg, mg or IU, on any syringe size.
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This page is an educational research reference and is not medical advice. Dose figures reflect the published record and what the community has converged on — starting points to weigh, not instructions. Consult a qualified healthcare provider before starting any protocol.