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Research chemical Published: limited Established use

DSIP: dosing, reconstitution and evidence

A nonapeptide isolated from rabbit brain during slow-wave sleep. Used for sleep onset and quality, though results in humans have been inconsistent.

Also known as Delta Sleep-Inducing Peptide

Educational research reference Cognitive & Sleep
Quick reference. Everything you need to run DSIP — dosing, frequency, reconstitution math for the vial sizes people actually buy, and what it stacks with. For anything specific to your situation, ask the Guru.

DSIP quick start

Route
SubQ
Typical dose
100–300 mcg
Frequency
Before bed
Half-life
Very short — roughly 7–40 minutes.
Cycle
As needed or 2–4 week courses.
Vial sizes sold
5mg or 10mg
These are the numbers people actually run, drawn from the published record and from what the community has settled on over time. Educational reference, not medical advice — a starting point to work from, and one you can adjust as you learn how you respond.

How to run it

How often
Before bed
Cycle length
As needed or 2–4 week courses.
Half-life
Very short — roughly 7–40 minutes.
Route
SubQ
Consistency matters more than perfect timing. Pick a slot in your day you will actually keep, and let DoseIQ handle the rest.

What people actually run

Long-standing sleep use with genuinely mixed reports — the community is split on whether it does much.

This is accumulated community practice — years of real-world use across a large number of people, converging on numbers that work. It is not a controlled trial, and for most compounds here no such trial exists or is ever likely to. That makes this the most reliable dosing signal available, and it is a good deal better than guessing.

What to expect

Most people tolerate DSIP well. Here is what is worth knowing going in, so nothing catches you by surprise.

Human sleep studies have produced mixed results — some show no effect versus placebo. Paradoxical stimulation is occasionally reported. Given the very short half-life, the mechanism behind any lasting effect is unclear.

Reconstitution guide

DSIP ships as a lyophilised powder and gets mixed with bacteriostatic water before use. How much water you add sets the concentration, which sets how many syringe units make up each dose. One unit on a U-100 syringe is 0.01 mL — the tables below do the arithmetic for the vial sizes you are most likely to be holding.

5mg vial most common

Water addedConcentration 100mcg300mcg
2mL (common) 2.5 mg/mL0.04 mL
4 units		0.12 mL
12 units
3mL 1.67 mg/mL0.06 mL
6 units		0.18 mL
18 units

10mg vial

Water addedConcentration 100mcg300mcg
2mL (common) 5 mg/mL0.02 mL
2 units		0.06 mL
6 units
3mL 3.33 mg/mL0.03 mL
3 units		0.09 mL
9 units
5 mg vial + 2.5 mL BAC water = 2 mg/mL — a 200 mcg dose = 10 units on a U-100 syringe. 10 mg vial + 3 mL = 3,333 mcg/mL — 200 mcg = 6 units.

Standard steps

  1. Inspect the vialConfirm the label and that the powder cake is intact. Do not use a cracked or compromised vial.
  2. Let it reach room temperatureSitting out for a few minutes reduces condensation inside the vial when the seal is broken.
  3. Disinfect both stoppersWipe the compound vial and the bacteriostatic water vial with a fresh alcohol swab and let them air-dry.
  4. Draw the bacteriostatic waterUse a sterile syringe to draw the volume you have chosen from the reconstitution table.
  5. Add the water down the vial wallInject slowly so it runs down the inside wall rather than spraying directly onto the powder. This limits foaming.
  6. Dissolve gentlySwirl or roll the vial between your hands until the cake dissolves. Never shake — agitation damages peptide bonds. The solution should end up clear.
  7. Label and refrigerateWrite the reconstitution date and concentration on the vial. Store at 2–8°C. Do not freeze.
Running a different vial size or water volume? The DoseIQ calculator works it out for any combination — mcg, mg or IU, on any syringe size.
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This page is an educational research reference and is not medical advice. DSIP is not approved for human use in any jurisdiction. Dose figures reflect the published record and what the community has converged on — starting points to weigh, not instructions. Consult a qualified healthcare provider before starting any protocol.