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Over the counter Published: limited Established use

DIM: dosing, timing and what to expect

A compound from cruciferous vegetables that pushes oestrogen metabolism toward weaker metabolites. Popular on TRT as a gentler alternative to an aromatase inhibitor.

Also known as diindolylmethane

Educational research reference Supplements
Quick reference. Everything you need to run DIM — dosing, frequency, reconstitution math for the vial sizes people actually buy, and what it stacks with. For anything specific to your situation, ask the Guru.

DIM quick start

Route
Oral
Typical dose
100–200 mg daily
Frequency
Daily
Half-life
Around 24 hours.
Cycle
Continuous or as needed.
These are the numbers people actually run, drawn from the published record and from what the community has settled on over time. Educational reference, not medical advice — a starting point to work from, and one you can adjust as you learn how you respond.

How to run it

How often
Daily
Cycle length
Continuous or as needed.
Half-life
Around 24 hours.
Route
Oral
Consistency matters more than perfect timing. Pick a slot in your day you will actually keep, and let DoseIQ handle the rest.

What people actually run

Frequently reached for as a "natural AI" on TRT. It shifts oestrogen metabolism rather than blocking its production, which is a different thing entirely.

This is accumulated community practice — years of real-world use across a large number of people, converging on numbers that work. It is not a controlled trial, and for most compounds here no such trial exists or is ever likely to. That makes this the most reliable dosing signal available, and it is a good deal better than guessing.

What to expect

Most people tolerate DIM well. Here is what is worth knowing going in, so nothing catches you by surprise.

The important misunderstanding: DIM does not lower total oestrogen the way anastrozole does — it changes which metabolites you make. Stacking it with an AI can overshoot into genuinely low oestrogen, which feels worse than high and wrecks joints, libido and mood. Pick one and titrate it against bloodwork. Harmlessly turns urine orange.

Preparing it

DIM does not need reconstituting — it comes ready to use.
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This page is an educational research reference and is not medical advice. Dose figures reflect the published record and what the community has converged on — starting points to weigh, not instructions. Consult a qualified healthcare provider before starting any protocol.