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Research chemical Published: human trials Extensive real-world use

CJC-1295 with DAC: dosing, reconstitution and evidence

A GHRH analog with a Drug Affinity Complex that binds albumin, extending its life from minutes to days. Produces a sustained elevation in GH and IGF-1 rather than pulses.

Also known as DAC:GRF, CJC-1295 DAC

Educational research reference Growth Hormone
Quick reference. Everything you need to run CJC-1295 with DAC — dosing, frequency, reconstitution math for the vial sizes people actually buy, and what it stacks with. For anything specific to your situation, ask the Guru.

CJC-1295 with DAC quick start

Route
SubQ
Typical dose
1–2 mg
Frequency
Once or twice weekly
Half-life
Approximately 6–8 days — the longest of the GH secretagogues.
Cycle
12 weeks on, 4 off is common.
Vial sizes sold
5mg or 2mg
These are the numbers people actually run, drawn from the published record and from what the community has settled on over time. Educational reference, not medical advice — a starting point to work from, and one you can adjust as you learn how you respond.

How to run it

How often
Once or twice weekly
Cycle length
12 weeks on, 4 off is common.
Half-life
Approximately 6–8 days — the longest of the GH secretagogues.
Route
SubQ
Consistency matters more than perfect timing. Pick a slot in your day you will actually keep, and let DoseIQ handle the rest.

What people actually run

Used where convenience matters more than pulsatility. Less popular than the no-DAC version but well established.

This is accumulated community practice — years of real-world use across a large number of people, converging on numbers that work. It is not a controlled trial, and for most compounds here no such trial exists or is ever likely to. That makes this the most reliable dosing signal available, and it is a good deal better than guessing.

What to expect

Most people tolerate CJC-1295 with DAC well. Here is what is worth knowing going in, so nothing catches you by surprise.

The DAC version holds GH elevated continuously rather than in natural pulses, which is why some people prefer the no-DAC form — it is a preference, not a safety line. Water retention, mild carpal tunnel symptoms and a bump in fasting glucose are the usual things to watch; all three tend to ease at a lower dose. If you have an active malignancy, sit this one out and talk to your doctor — GH is a growth signal and that is not a call to make on your own.

Known interactions

Interactions involving CJC-1295 with DAC's drug class that DoseIQ screens for. Each one cites where it comes from — an FDA label section or the published record — because an interaction warning you can't trace is just noise.

Caution GH peptides push blood sugar against your diabetes medication

Growth hormone raises glucose and insulin resistance — it works directly against glucose-lowering medication.

What to do: Fasting glucose and HbA1c are worth tracking; medication doses sometimes need adjusting. Your prescriber should know GH peptides are in the picture.

Source: GH pharmacology; tesamorelin label §7

DoseIQ screens your whole protocol against these rules automatically — every compound, prescription and supplement you track, cross-checked as you add them. Serious flags are always free.

Reconstitution guide

CJC-1295 with DAC ships as a lyophilised powder and gets mixed with bacteriostatic water before use. How much water you add sets the concentration, which sets how many syringe units make up each dose. One unit on a U-100 syringe is 0.01 mL — the tables below do the arithmetic for the vial sizes you are most likely to be holding.

5mg vial most common

Water addedConcentration 1mg2mg
2mL (common) 2.5 mg/mL0.40 mL
40 units		0.80 mL
80 units
3mL 1.67 mg/mL0.60 mL
60 units		1.20 mL
120 units *

2mg vial

Water addedConcentration 1mg2mg
2mL (common) 1 mg/mL1.00 mL
100 units		2.00 mL
200 units *
3mL 666.67 mcg/mL1.50 mL
150 units *		3.00 mL
300 units *

* More than 100 units — that is more than a single U-100 insulin syringe holds. Either use a larger syringe, split it across two draws, or mix with less water to concentrate it. Adding less water is usually the easier fix.

5 mg vial + 1 mL BAC water = 5 mg/mL — a 1 mg dose = 20 units on a U-100 syringe. 2 mg vial + 1 mL = 2 mg/mL — 1 mg = 50 units.

Standard steps

  1. Inspect the vialConfirm the label and that the powder cake is intact. Do not use a cracked or compromised vial.
  2. Let it reach room temperatureSitting out for a few minutes reduces condensation inside the vial when the seal is broken.
  3. Disinfect both stoppersWipe the compound vial and the bacteriostatic water vial with a fresh alcohol swab and let them air-dry.
  4. Draw the bacteriostatic waterUse a sterile syringe to draw the volume you have chosen from the reconstitution table.
  5. Add the water down the vial wallInject slowly so it runs down the inside wall rather than spraying directly onto the powder. This limits foaming.
  6. Dissolve gentlySwirl or roll the vial between your hands until the cake dissolves. Never shake — agitation damages peptide bonds. The solution should end up clear.
  7. Label and refrigerateWrite the reconstitution date and concentration on the vial. Store at 2–8°C. Do not freeze.
Running a different vial size or water volume? The DoseIQ calculator works it out for any combination — mcg, mg or IU, on any syringe size.
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This page is an educational research reference and is not medical advice. CJC-1295 with DAC is not approved for human use in any jurisdiction. Dose figures reflect the published record and what the community has converged on — starting points to weigh, not instructions. Consult a qualified healthcare provider before starting any protocol.