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Research chemical Published: human trials Emerging use

Cagrilintide: dosing, reconstitution and evidence

A long-acting amylin analog that produces satiety through a mechanism distinct from GLP-1 — which is why it is studied combined with semaglutide (as CagriSema).

Also known as AM833

Educational research reference Metabolic & Weight
Quick reference. Everything you need to run Cagrilintide — dosing, frequency, reconstitution math for the vial sizes people actually buy, and what it stacks with. For anything specific to your situation, ask the Guru.

Cagrilintide quick start

Route
SubQ
Typical dose
0.3–2.4 mg
Frequency
Once weekly
Half-life
Roughly 7–8 days.
Cycle
Not established.
Vial sizes sold
10mg or 5mg
These are the numbers people actually run, drawn from the published record and from what the community has settled on over time. Educational reference, not medical advice — a starting point to work from, and one you can adjust as you learn how you respond.

How to run it

How often
Once weekly
Cycle length
Not established.
Half-life
Roughly 7–8 days.
Route
SubQ
Consistency matters more than perfect timing. Pick a slot in your day you will actually keep, and let DoseIQ handle the rest.

What people actually run

Emerging, mostly among people already running a GLP-1-class drug and looking to add amylin.

This is accumulated community practice — years of real-world use across a large number of people, converging on numbers that work. It is not a controlled trial, and for most compounds here no such trial exists or is ever likely to. That makes this the most reliable dosing signal available, and it is a good deal better than guessing.

What to expect

Most people tolerate Cagrilintide well. Here is what is worth knowing going in, so nothing catches you by surprise.

Investigational, not approved. Nausea is common. Combining with any GLP-1-class drug compounds the GI burden.

Known interactions

Interactions involving Cagrilintide's drug class that DoseIQ screens for. Each one cites where it comes from — an FDA label section or the published record — because an interaction warning you can't trace is just noise.

Caution Slowed stomach emptying can shift this medication's absorption

The whole GLP-1 class — semaglutide, tirzepatide, retatrutide — delays gastric emptying, which changes how narrow-margin oral drugs (thyroid, warfarin, the pill) absorb.

What to do: Keep timing consistent, and re-check the relevant lab (TSH, INR) a few weeks after starting or increasing the dose.

Source: FDA labels, GLP-1 class §7

Caution Stimulant + GLP-1-class — appetite suppressed from both sides

Both suppress appetite; together intake can drop genuinely too low without feeling like anything is wrong.

What to do: Track weight and actually eat protein on schedule — hunger stops being a reliable signal on this combination.

Source: Class pharmacology; widely reported in practice

Caution Lithium + GLP-1-class — dehydration moves lithium levels

Lithium levels track hydration, and a rough titration week — nausea, vomiting, big drops in intake — concentrates lithium.

What to do: Drink deliberately during dose increases, and treat persistent vomiting as a reason to check a lithium level, not just wait out.

Source: Lithium label (volume depletion); GLP-1 class GI profile

DoseIQ screens your whole protocol against these rules automatically — every compound, prescription and supplement you track, cross-checked as you add them. Serious flags are always free.

Reconstitution guide

Cagrilintide ships as a lyophilised powder and gets mixed with bacteriostatic water before use. How much water you add sets the concentration, which sets how many syringe units make up each dose. One unit on a U-100 syringe is 0.01 mL — the tables below do the arithmetic for the vial sizes you are most likely to be holding.

10mg vial most common

Water addedConcentration 0.3mg2.4mg
2mL (common) 5 mg/mL0.06 mL
6 units		0.48 mL
48 units
3mL 3.33 mg/mL0.09 mL
9 units		0.72 mL
72 units

5mg vial

Water addedConcentration 0.3mg2.4mg
2mL (common) 2.5 mg/mL0.12 mL
12 units		0.96 mL
96 units
3mL 1.67 mg/mL0.18 mL
18 units		1.44 mL
144 units *

* More than 100 units — that is more than a single U-100 insulin syringe holds. Either use a larger syringe, split it across two draws, or mix with less water to concentrate it. Adding less water is usually the easier fix.

10 mg vial + 1 mL BAC water = 10 mg/mL — a 1 mg dose = 10 units on a U-100 syringe. 5 mg vial + 1 mL = 5 mg/mL — 1 mg = 20 units.

Standard steps

  1. Inspect the vialConfirm the label and that the powder cake is intact. Do not use a cracked or compromised vial.
  2. Let it reach room temperatureSitting out for a few minutes reduces condensation inside the vial when the seal is broken.
  3. Disinfect both stoppersWipe the compound vial and the bacteriostatic water vial with a fresh alcohol swab and let them air-dry.
  4. Draw the bacteriostatic waterUse a sterile syringe to draw the volume you have chosen from the reconstitution table.
  5. Add the water down the vial wallInject slowly so it runs down the inside wall rather than spraying directly onto the powder. This limits foaming.
  6. Dissolve gentlySwirl or roll the vial between your hands until the cake dissolves. Never shake — agitation damages peptide bonds. The solution should end up clear.
  7. Label and refrigerateWrite the reconstitution date and concentration on the vial. Store at 2–8°C. Do not freeze.
Running a different vial size or water volume? The DoseIQ calculator works it out for any combination — mcg, mg or IU, on any syringe size.
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This page is an educational research reference and is not medical advice. Cagrilintide is not approved for human use in any jurisdiction. Dose figures reflect the published record and what the community has converged on — starting points to weigh, not instructions. Consult a qualified healthcare provider before starting any protocol.