All compounds
Research chemical Published: human trials Emerging use

ARA-290: dosing, reconstitution and evidence

An 11-amino-acid peptide derived from erythropoietin that activates the innate repair receptor without EPO's effect on red blood cells. Notably, it has real human trial data in small-fiber neuropathy and sarcoidosis-related neuropathic pain.

Also known as Cibinetide

Educational research reference Healing & Recovery
Quick reference. Everything you need to run ARA-290 — dosing, frequency, reconstitution math for the vial sizes people actually buy, and what it stacks with. For anything specific to your situation, ask the Guru.

ARA-290 quick start

Route
SubQ
Typical dose
4 mg
Frequency
Daily
Half-life
Approximately 2 hours.
Cycle
Trials ran 28 days; longer use is uncharacterized.
Vial sizes sold
8mg or 16mg
These are the numbers people actually run, drawn from the published record and from what the community has settled on over time. Educational reference, not medical advice — a starting point to work from, and one you can adjust as you learn how you respond.

How to run it

How often
Daily
Cycle length
Trials ran 28 days; longer use is uncharacterized.
Half-life
Approximately 2 hours.
Route
SubQ
Consistency matters more than perfect timing. Pick a slot in your day you will actually keep, and let DoseIQ handle the rest.

What to expect

Most people tolerate ARA-290 well. Here is what is worth knowing going in, so nothing catches you by surprise.

Among the better-studied compounds here — Phase 2 human data exists — but still not approved. Does not raise hematocrit, unlike EPO.

Reconstitution guide

ARA-290 ships as a lyophilised powder and gets mixed with bacteriostatic water before use. How much water you add sets the concentration, which sets how many syringe units make up each dose. One unit on a U-100 syringe is 0.01 mL — the tables below do the arithmetic for the vial sizes you are most likely to be holding.

8mg vial most common

Water addedConcentration 4mg
2mL (common) 4 mg/mL1.00 mL
100 units
3mL 2.67 mg/mL1.50 mL
150 units *

16mg vial

Water addedConcentration 4mg
2mL (common) 8 mg/mL0.50 mL
50 units
3mL 5.33 mg/mL0.75 mL
75 units

* More than 100 units — that is more than a single U-100 insulin syringe holds. Either use a larger syringe, split it across two draws, or mix with less water to concentrate it. Adding less water is usually the easier fix.

8 mg vial + 1 mL BAC water = 8 mg/mL — a 4 mg dose = 50 units on a U-100 syringe. 16 mg vial + 2 mL = 8 mg/mL — 4 mg = 50 units.

Standard steps

  1. Inspect the vialConfirm the label and that the powder cake is intact. Do not use a cracked or compromised vial.
  2. Let it reach room temperatureSitting out for a few minutes reduces condensation inside the vial when the seal is broken.
  3. Disinfect both stoppersWipe the compound vial and the bacteriostatic water vial with a fresh alcohol swab and let them air-dry.
  4. Draw the bacteriostatic waterUse a sterile syringe to draw the volume you have chosen from the reconstitution table.
  5. Add the water down the vial wallInject slowly so it runs down the inside wall rather than spraying directly onto the powder. This limits foaming.
  6. Dissolve gentlySwirl or roll the vial between your hands until the cake dissolves. Never shake — agitation damages peptide bonds. The solution should end up clear.
  7. Label and refrigerateWrite the reconstitution date and concentration on the vial. Store at 2–8°C. Do not freeze.
Running a different vial size or water volume? The DoseIQ calculator works it out for any combination — mcg, mg or IU, on any syringe size.
Track this in DoseIQ Browse all compounds

This page is an educational research reference and is not medical advice. ARA-290 is not approved for human use in any jurisdiction. Dose figures reflect the published record and what the community has converged on — starting points to weigh, not instructions. Consult a qualified healthcare provider before starting any protocol.